Saints
Preview
NFL Week 3 Betting Preview: New Orleans Saints at Seattle Seahawks
📍 Lumen Field – Seattle, WA
📅 Sunday, Sept. 21, 2025 | ⏰ 3:05 p.m. CT | 📺 FOX
Betting Lines (as of midweek):
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Spread: Seahawks -7.5 (-110) | Saints +7.5 (-110)
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Moneyline: Seahawks -340 | Saints +270
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Over/Under: 43.5 points (O -110 | U -110)
Matchup Breakdown:
The New Orleans Saints (0-2) hit the road for the first time this season, desperate to avoid an 0-3 start under rookie head coach Kellen Moore. They’ve been competitive in both losses but penalties and turnovers continue to derail progress. Spencer Rattler showed flashes last week, tossing three touchdowns, but he remains winless as an NFL starter (0-9). The bright spot is still Alvin Kamara, who’s averaging nearly 100 total yards per game and remains the engine of the offense.
The Seattle Seahawks (2-1), meanwhile, are riding high after dismantling the Saints 44-13 in Week 2. Sam Darnold looks comfortable in Seattle’s offense, while rookie playmaker Tory Horton delivered a record-setting punt return TD and continues to emerge as a difference-maker. Add in the thunder-and-lightning backfield of Kenneth Walker III and Zach Charbonnet, and Seattle boasts one of the more balanced offenses in the NFC.
Defensively, Seattle is generating turnovers at a high rate, while New Orleans has been plagued by costly penalties (31 through two games). At home in the noise of Lumen Field, that could prove disastrous.
Key Trends:
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Saints are 1-6 ATS in their last seven games overall.
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Seahawks are 5-2 ATS in their last seven home games.
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The Over has hit in 4 of Seattle’s last 5 home games.
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Saints have committed the most penalties in the NFL through two weeks (31).
Pick & Prediction:
It’s hard to trust the Saints’ discipline and execution right now, especially on the road in one of the NFL’s toughest environments. Seattle’s playmakers are firing on all cylinders, and New Orleans has shown no ability to limit explosive plays.
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Pick Against the Spread: Seahawks -7.5
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Moneyline Lean: Seahawks (-340) — safe for parlays, but expensive solo.
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Over/Under: Over 43.5 — Seattle should push close to 30 points again, and even if Rattler pads late numbers, this total is within reach.
Final Score Prediction: Seahawks 31, Saints 17
