October 12, 2025 | Charlotte, NC – The Dallas Cowboys (2-2-1) head to Bank of America Stadium this Sunday to take on the Carolina Panthers (3-2) in what shapes up as an intriguing Week 6 clash between two teams trending in opposite directions. Kickoff is set for 12:00 PM CT, with both squads looking to solidify their early-season identity — and bettors are taking notice.

The Cowboys enter as slight road favorites at -3 (-115), while the Panthers are priced at +3 (-105). The over/under sits at 44.5 points, reflecting expectations for a balanced, mid-scoring affair.

Betting Angle: Can the Panthers Keep It Close?

Carolina enters Week 6 having won back-to-back home games, including last week’s 27–24 victory over the Miami Dolphins. They’ve quietly developed a physical offensive identity built around a resurgent ground attack, rushing for 239 yards against Miami and posting 26 first downs.

That momentum makes them a live underdog this week. The Panthers’ recent success at home — coupled with the Cowboys’ inconsistencies away from AT&T Stadium — has created value for bettors taking the Panthers +3 (-105).

Head coach Dave Canales has found balance through the legs of Chuba Hubbard and Miles Sanders, allowing quarterback Bryce Young to play with more confidence and rhythm. The rookie signal-caller has improved his efficiency over the last two weeks, completing 68% of his passes with three touchdowns and no turnovers.

If Carolina can control time of possession and establish the run early, they’ll have a chance to frustrate the Cowboys’ defense — especially one that’s been forced to blitz more often to generate pressure without Micah Parsons at 100%.

Dallas Offense Heating Up

The Cowboys come off their most complete offensive performance of the year, a 37–22 win over the New York Jets. Quarterback Dak Prescott threw for 236 yards and four touchdowns, while Javonte Williams carried the load with 135 yards rushing and another score.

Prescott, who has yet to throw an interception this season, continues to look comfortable within offensive coordinator Brian Schottenheimer’s balanced scheme. He has also developed quick chemistry with tight end Jake Ferguson, who now ranks top-five among tight ends in receptions.

However, this week’s test could be different. The Panthers’ defense — led by linebacker Frankie Luvu and edge rusher Brian Burns — has forced key takeaways in each of their last three games. Carolina has allowed just 17.5 points per game at home, and their front seven has excelled at generating pressure without heavy blitzing.

Expect Dallas to rely on the short passing game early to neutralize that Carolina rush. If the Cowboys’ offensive line, which remains without Tyler Smith and Tyler Guyton, can keep Prescott clean, they’ll look to attack vertically with George Pickens and Brandin Cooks.

Head-to-Head Trends

• Dallas has won three of the last four meetings against Carolina.

• The Cowboys are 5-2 ATS in their last seven road games.

• The Panthers are 4-1 ATS in their last five games at home.

• The under has hit in four of the last six matchups between these teams.

In their most recent meeting, Dallas defeated Carolina 33–10 in 2024 behind a dominant defensive performance. This year, however, the Panthers appear more balanced offensively, and home-field advantage could make all the difference.

Key Player Props to Watch

• Dak Prescott Over 1.5 Passing TDs (-140): Carolina’s defense has struggled against tight ends and slot receivers — both strong suits for Prescott’s passing attack.

• Miles Sanders Over 54.5 Rushing Yards (-110): Dallas allowed over 180 rushing yards to the Jets last week. Sanders’ workload should increase as Carolina leans on ball control.

• Jake Ferguson Anytime TD (+180): He’s become Prescott’s go-to red zone option, scoring three times in his last two outings.

Prediction: Panthers Keep It Close

The Cowboys may have the star power, but the Panthers’ discipline at home and renewed offensive rhythm make them an appealing underdog. Expect Dallas to start fast but Carolina to grind their way back into contention in the second half.

Final Score Prediction: Cowboys 27, Panthers 24