NEW ORLEANS (Oct. 5, 2025) – After two straight weeks on the road, the New Orleans Saints return to the Caesars Superdome in search of their first win of the 2025 season. Their Week 5 opponent, the New York Giants, enter with momentum after edging the Los Angeles Chargers 21-18 last week. For the Saints, Sunday’s matchup presents not only a chance to even the all-time series at 17-17 but also an opportunity to build on recent dominance against New York.

The Saints have taken each of the last two meetings (2023 and 2024) and seven of the past ten. That history, combined with the home-field edge of the Dome, gives New Orleans reason for optimism in a pivotal early-season matchup.

NFC South at a Glance

Around the division, Week 5 offers compelling storylines. The Carolina Panthers (1-3) host the Miami Dolphins (1-3) in a battle of struggling squads. The Tampa Bay Buccaneers (3-1), riding a hot start, face a challenging road test against the equally strong Seattle Seahawks (3-1). The Atlanta Falcons (2-2), meanwhile, enjoy the season’s first bye week.

For New Orleans, a win would not only break into the win column but also keep them within striking distance in a division still wide open after the first month.

Key Injury Report

The Giants enter Sunday’s contest shorthanded. Rookie star wide receiver Malik Nabers has been lost for the season after suffering a torn ACL, a devastating blow to New York’s offensive firepower. Wideout Darius Slayton is expected to step into a larger role, having already made key grabs in the Week 4 victory.

For New Orleans, wide receiver Dart is questionable with a hamstring issue, limiting depth at the position. Defensively, the Saints’ secondary got a boost with the return of Alontae Taylor, though tackling discipline remains a concern after missed opportunities last week.

Matchup to Watch: Slayton vs. Saints Secondary

With Nabers sidelined, all eyes will turn to Darius Slayton and how New Orleans’ defensive backs handle his speed. Slayton has shown flashes of being a reliable deep threat, and quarterback Daniel Jones leaned on him heavily in the Giants’ Week 4 win.

The Saints’ secondary created a turnover last week with an interception but also allowed chunk gains due to missed tackles. Containing Slayton while preventing explosive plays will be critical to slowing New York’s passing attack. Expect Taylor and veteran Marshon Lattimore to see heavy snaps in coverage.

Saints’ Ground Game in Focus

Offensively, New Orleans will look to build off its best rushing performance of the season in Week 4. The running back tandem combined for over 120 yards on the ground, giving balance to an offense that has too often been one-dimensional early this year.

Against the Giants’ front seven, the Saints will test their ability to control the trenches. New York has allowed opponents to sustain drives with physical running, making this a potential area of advantage for New Orleans. If the Saints can stay ahead of the chains with consistent runs, it will open up opportunities for quarterback Spencer Rattler to find his rhythm.

What’s at Stake

The stakes are clear for New Orleans. At 0-4, desperation is setting in, and Sunday represents a golden chance to turn the season around in front of the home crowd. Breaking through with a win could also reestablish confidence in head coach Dennis Allen’s locker room, while extending dominance over a familiar opponent.

For the Giants, the matchup is about sustaining momentum. Their win over the Chargers stopped early-season doubts, and a road victory in New Orleans would put them above .500 while further validating their growth under head coach Brian Daboll.

Prediction

Expect a physical, emotional game as both teams enter with urgency. The Saints will lean on their running game and home-field advantage, while the Giants’ hopes rest on Jones’ connection with Slayton and a defense that has played opportunistically in spurts.

Regardless of the outcome, the atmosphere inside Caesars Superdome promises to be electric as New Orleans chases its first win of 2025 and the Giants look to prove their Week 4 success was no fluke.